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GsMTx4 TFA (1209500-46-8 free base)
🥰Excellent
Catalog No. TP1300
Alias GsMTx4 TFA
GsMTx4 TFA (1209500-46-8 free base) is a spider venom peptide that selectively inhibits cation permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families.
GsMTx4 TFA (1209500-46-8 free base)
🥰Excellent
Purity: 99.81%
Catalog No. TP1300Alias GsMTx4 TFA
GsMTx4 TFA (1209500-46-8 free base) is a spider venom peptide that selectively inhibits cation permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $468 | In Stock | In Stock | |
| 5 mg | $1,080 | In Stock | In Stock | |
| 10 mg | $1,450 | In Stock | In Stock | |
| 25 mg | $2,150 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.81%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | GsMTx4 TFA (1209500-46-8 free base) is a spider venom peptide that selectively inhibits cation permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. |
| In vitro | METHODS: GsMTx4 TFA (5 μM) was tested on outside-out patches of HEK cells transfected with mouse Piezo1 cDNA. RESULTS GsMTx4 TFA reduced Piezo1-mediated charge transfer to 38% of its initial level. [1] METHODS: Using C57BL/6 mice as samples, organotypic cerebellar slices (OCS) were prepared and treated with Piezo1 specific activator Yoda-1 (10 μM, 48 hours) or Piezo1 peptide inhibitor GsMTx4 (500 nM, 48 hours). Hours) organotypic cerebellar slices were processed to study how activating or blocking Piezo1 affects myelination. RESULTS GsMTx4 TFA may rescue psychotin-induced demyelination. [3] METHODS: MCF10A cells were incubated with adipokines for 24-72 hours. Use GSMTx4 TFA at a concentration of 2.5 μM as a mechanosensitive Ca2+ channel inhibitor for 16 hours. RESULTS GSMTx4 TFA significantly reduced leptin-induced AMPK and MLC-2 phosphorylation. [4] |
| In vivo | METHODS: The effects of blocking the Piezo1/CaN/NFAT1 signaling axis by intra-articular injection of GsMTx4 TFA on ACLT-induced osteoarthritis (OA) rats were studied. Taking into account the rapid clearance of synovial fluid, we performed 7, 14, 21, 28 ACLT + H-Gsmtx4 groups at two different frequencies (once a week in the H-GsMTx4 TFA group and once every two weeks in the L-GsMTx4 TFA group). , 35, 42 and 49 days and ACLT + L-Gsmtx4 group were intra-articularly injected with 100 μL of 40 μM Gsmtx4 TFA on 7, 21, 35 and 49 days after surgery. RESULTS GsMTx4 TFA can improve OA in rats by inhibiting apoptosis and imbalance of anabolism and catabolism. [2] |
| Synonyms | GsMTx4 TFA |
| Molecular Weight | 4216.93 |
| Formula | C187H279N48O48S6F3 |
| Smiles | [H]NCC(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CC(N)=O)C(N1CCC[C@H]1C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N2CCC[C@H]2C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(O)=O)CC3=CC=CC=C3)=O)=O)CC4=CC=CC=C4)=O)=O)CS)=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)CS)=O)=O)=O)=O)=O)=O)CS)=O)CS)=O)=O)CC(O)=O)=O)CC(O)=O)=O)=O)=O)=O)CS)=O)=O)CC6=CNC7=C6C=CC=C7)=O)CC8=CNC9=C8C=CC=C9)=O)CC%10=CC=CC=C%10)=O)=O)=O)CS)=O.O=C(O)C(F)(F)F |
| Relative Density. | no data available |
| Sequence | Gly-Cys-Leu-Glu-Phe-Trp-Trp-Lys-Cys-Asn-Pro-Asn-Asp-Asp-Lys-Cys-Cys-Arg-Pro-Lys-Leu-Lys-Cys-Ser-Lys-Leu-Phe-Lys-Leu-Cys-Asn-Phe-Ser-Phe |
| Sequence Short | GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF |
| Storage | store at low temperature,keep away from moisture,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 237.5 mg/mL (56.32 mM)  H2O: 66.66 mg/mL (15.81 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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